Uncharted 2: Among Thieves is the big winner of the E3 2009 Game Critics Awards, scooping the prestigious Best Of Show award, alongside Best Console Game and Best Action/Adventure Game. Scribblenauts was the only other game to take home multiple honours, pocketing Best Original Game and Best Handheld Game.

The Game Critics Awards are voted for by a panel of editors from 29 North American videogame media outlets. Eligible games must be available to play at the show, though not necessarily to everyone. Occasionally playable demos are presented to the panel behind closed doors, or even at special pre-event previews, leading some to question the judging process.

Regardless, E3 Best in Show is an indication not just of quality but also of commercial clout. Since 2002, all videogame winners of the title (hardware is also eligible) have sold more than 1 million units at retail. Recent winners include Fallout 3, Half-Life 2, Spore and Rock Band.

Hit the jump for a full breakdown of the winners, and let us know what you think of the results in the comments below.

Best Of Show
Uncharted 2: Among Thieves
(Naughty Dog/Sony Computer Entertainment America for PlayStation 3)

Best Original Game
Scribblenauts
(5TH Cell/Warner Bros Interactive Entertainment for Nintendo DS)

Best Console Game
Uncharted 2: Among Thieves
(Naughty Dog/Sony Computer Entertainment America for PlayStation 3)

Best PC Game
Star Wars: The Old Republic
(BioWare Austin/LucasArts)

Best Handheld Game
Scribblenauts
(5TH Cell/Warner Bros Interactive Entertainment for Nintendo DS)

Best Hardware/Peripheral
“Project Natal”
(Microsoft for Xbox 360)

Best Action Game
Modern Warfare 2
(Infinity Ward/Activision for PlayStation 3, Xbox 360, PC)

Best Action/Adventure Game
Uncharted 2: Among Thieves
(Naughty Dog/Sony Computer Entertainment America for PlayStation 3)

Best Role Playing Game
Mass Effect 2
(BioWare/Electronic Arts for Xbox 360, PC)

Best Racing Game
Split/Second
(Black Rock/Disney Interactive Studios for PlayStation 3, Xbox 360, PC)

Best Sports Game
Fight Night Round 4
(EA Canada/EA Sports for PlayStation 3, Xbox 360)

Best Fighting Game
Tatsunoko vs. Capcom: Ultimate All-Stars
(Eighting/Capcom for Nintendo Wii)

Best Strategy Game
Supreme Commander 2
(Gas Powered Games/Square-Enix for Xbox 360, PC)

Best Social/Casual/Puzzle
DJ Hero
(Freestyle/Red Octane/Activision for PlayStation 3, Xbox 360, Wii)

Best Online Multiplayer
Left 4 Dead 2
(Valve/EAP for Xbox 360, PC)