A few days ago Nigoro and the guys at Nicalis (see: the WiiWare version of Cave Story) announced that the PC game La-Mulana is getting some dressing up and a release on WiiWare in late 2009. The game is a gorgeous homage to classic 80s side-scrollers, and follows archeologist Dr. Lemeza Kosugi as he tries the ruins of a famed ancient civilization. The visuals and audio have been totally redone, and while still very reminiscent of the classic 16-bit games, it is no longer limited completely by those restrictions.
Pricing has not yet been announced, but check out the awesome video above. The whole thing makes me want to play Super Castlevania IV.